Overview
Pepzol Capsuleis a prescription medicine that is used for the short-term treatment ofulcersin the upper part of the small intestine (duodenal ulcer). This medicine works bypreventingthe amount of acid production in the stomach by blocking the organic enzyme system. This medicine helps by reducing the level of acid in the stomach. Pepzol Capsule is also used for the short-term treatment of stomach ulcer, to treatheartburnandindigestioncaused byGERD, for the short-term treatment of inflammation of the food pipe, for the long-term treatment of overproduction of gastric acid (Zollinger-Ellisonsyndrome), for the long-term treatment ofcancerof the endocrine gland, and for the long-term treatment of increase in the number of mast cells in the body (systemicmastocytosis).
Pepzol Capsule may also be used along with other medicines in the treatment of certain conditions as recommended by the doctor. It is used withClarithromycin, orAmoxicillinto treatulcersin the upper part of the small intestine called as duodenal ulcers. It is also used together withClarithromycin, orMetronidazoleto remove Helicobacter pylori bacteria which leads to stomachulcers.
How to use
Read the directions on the product label, patient guide, ormedicineguide provided by the medicine company or your pharmacist before starting to usePepzol Capsule. If you have any questions related to this medicine, ask your doctor or pharmacist. Consume this medicine as recommended by your doctor.
Pepzol Capsuleis consumed 1 hour before food. Swallow the Pepzol capsules whole. Do not chew or crush the capsules. Pepzol Capsule is consumed usually in the morning.
Typical Dosage
The typical dose of Pepzol is 20-40 mg once daily for 4-8 weeks. The usual dose for children is 5-20 mg once daily (for inflammation of the food pipe (erosive esophagitis) and acid reflux (gastroesophageal reflux disease). This medicine is typically used for a period of 8 weeks forulcersin the upper part of the small intestine (duodenal ulcer), 8 weeks for stomach ulcers, and 4 weeks for digestive disorder in which stomach acid flows back into the food pipe (gastroesophageal reflux disease). It takes 1-2 hours for this medicine to start to work. This medicine is not known to be habit-forming.
This medicine should be used on anas-needed basis. Pepzol may be prescribed for the long-term treatment of conditions such as excessive production of stomach acid (Zollinger-EllisonSyndrome).
If using the delayed-release form of thismedicine, do not crush or chew the medicine, unless indicated on the package. Crushing or chewing of the medicine can result in unpleasant taste resulting in patients not following the medicine schedule. Crushing or chewing can also release all of the medicine at once, resulting in a decrease of effectiveness and a possible increase in side-effects.
If using the liquid form of thismedicine, measure the dose using the provided measuring cup, spoon, or dropper. Before pouring the medicine into the measuring device, you should check the measurement markings carefully. Then, pour the dose amount into the device. After use, clean and store the measuring device in a safe place for your next use. You should not use a tablespoon or teaspoon as the dose measuring devices since it can result in an incorrect dose. If indicated on the product package, shake themedicinebefore use.
Talk to Your Doctor
Talk to your doctor if you develop new symptoms. Tell your doctor if conditions like weight loss, problems while swallowing, stomachpain,indigestion, vomiting (food or blood), blackstools, severediarrhea, severe liver problems and skin reaction occurs. If you have issues with the health of your liver, a low dose is required for the maintenance of inflammation of the food pipe (erosive esophagitis). You should consult with your doctor before stopping the use of Pepzol.
Older patients may see an increase in the incidence ofside-effectswith this medicine. As a result, a lower dose may be recommended for older patients.
Use in Children
If you are givingPepzol Capsuleto a child, be sure to use a product that is meant for children. Before giving this medicine to a child, use the child's weight or age to find the right dose from the product package. You can also read thedosage sectionof this page to know the correct dose for your child. Else, consult with your doctor and follow their recommendation.
Storage
You should storePepzol CapsuleStore Pepzol delayed-release capsules between 15°C and 30°C (59°F and 86°F). Store Pepzol delayed-release oral suspension at 25°C (77°F), permitted to 15–30°C (59–86°F), away from moisture, and away from light. Store themedicineaway from the reach of children andpets.
Medicines may be prescribed for uses other than those listed in the medicine guide. Do not usePepzol Capsulefor conditions for which it was not prescribed. Do not give Pepzol Capsule to other people who might have the same conditions or symptoms that you have. Self-medication may harm them.
PepzolDosage
Dosage forulcers in the upper part of small intestine
Adult
Recommended: 20 mg once per day for 2 weeks
Maximum: 40 mg once a day for 4 weeks
Dosage forstomach ulcer
Adult
Recommended: 20 mg once a day for 4 weeks
Maximum: 40 mg once a day for 8 weeks
Dosage foracid reflux
Adult
Recommended: 20 mg once a day for 4-8 weeks
Children (age 1-16 years and weight between 5-10 kg (11-22 lbs))
Recommended: 5 mg/day
Children (age 1-16 years and weight between 10-20 kg (22-44 lbs))
Recommended: 10 mg/day
Children (age 1-16 years and weight more than 20 kg (44 lbs))
Recommended: 20 mg/day
Dosage forinflammation of the food pipe (erosive esophagitis)
Adult
Recommended: 20 mg/day
Children (age 1-16 years and weight between 5-10 kg (11-22 lbs))
Recommended: 5 mg/day
Children (age 1-16 years and weight between 10-20 kg (22 - 44 lbs))
Recommended: 10 mg/day
Children (age 1-16 years and weight more than 20 kg (44 lbs))
Recommended: 20 mg/day
Dosage forexcessive production of stomach acid
Adult (dose adjustment should be followed as per the patient needs and continue for as long as clinically required.)
Recommended: 60 mg once per day
Maximum: 120 mg thrice a day
Missed Dose
Take the missed dose as soon as you remember. However, if the time for the next dose is almost there, then skip the missed dose and follow the regular dosing schedule. Avoid taking a repeated dose to make up for a missed one.
Overdose
What to do if you overdose on Pepzol?
No specific antidote for an overdose of Pepzol is available. The treatment depends on its symptoms.
Symptoms of an overdose of Pepzol
If you use too much of this medicine, it could lead to dangerous levels of the medicine in your body. In such cases, symptoms of an overdose may include:
Blurred vision
Confusion
Drowsiness
Dry mouth
Excessive sweating
Headache
Nausea
Rapid heartbeat
The feeling of warmth and rapid reddening of the upper chest, neck, or face (flushing)
Vomiting
If you think you have overdosed on Pepzol Capsule, call a poison control center immediately. You can look up the poison control center information from thePoison Center Finderat TabletWise.com.
Side-effects in Children
Pepzolmay cause an increased risk ofside-effectsin children. Children using this medicine may see an increased risk of respiratory system problems, andfever.
Long-term Use
Use of Pepzol for a long time may lead to long-term inflammation of the stomach (atrophicgastritis) and increases the risk of bone disease (osteoporosis) relatedfracturesof the spine, hip or wrist.
Pepzol Side-effects
The following side-effects may commonly occur when usingPepzol Capsule. If any of these side-effects worsen or last for a long time, you should consult with your doctor:
Abnormal growth (benignpolyps) in the stomach
Constipation
Diarrhea
Gasformation
Headache
Nausea
Stomachpain
Vomiting
The following side-effects may commonly occur in older patients on the use of Pepzol Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Diarrhea
Fracturesof the hip, wrist, and spine
Gasformation
Headache
Nausea
Stomachpain
Vomiting
Weakened and brittle bones (osteoporosis)
The following side-effects may commonly occur in children when usingPepzol Capsule. Discuss with your doctor if any of these side-effects last for a long time or are severe:
Accidental injury
Fever
Respiratory diseases
Rarely, the use of Pepzol Capsule may cause the following side-effects:
Aggression
Back pain
Backflow of acid from the stomach (acid regurgitation)
Cough
Dizziness
Dry mouth
Enlarged breasts in men
Feeling of discomfort
Feeling sleepy
Hair loss
Increased liver enzymes
Increased sweating
Inflammation inside the mouth
Inflammation of the skin (dermatitis)
Insomnia
Joint pain
Musclepain
Muscle weakness
Physical weakness due to lack of energy
Severeitching
Skin rash
Swelling of the feet and ankles
Taste changes
Tingling sensation
Upper respiratory infection
Vertigo
The following severe side-effects may also occur when usingPepzol Capsule:
Severe skin allergic reactions such as Stevens-Johnsonsyndrome, or erythema multiforme
Symptoms:skin rashes, the formation of bubble under the skin due to infection (blistering of skin), removal of the outer layer of skin (skin peeling), highfeverjoint pain
Liver diseases such asjaundiceor liver failure
Symptoms:yellowing of skin, dark colored urinetiredness
Blood disorders such as reduced number of white blood cells andplatelets
Symptoms:weakness, tear of blood vessels in the skin due to injury (bruising) more likely to get an infection
Low levels ofsodiumin the blood
Symptoms:weakness, vomiting uncontrolled muscle movements
Low levels of magnesium in the blood
Symptoms:fatigue, uncontrolled muscle contractions, mentalconfusion(disorientation), convulsions,dizzinessincreased heartbeat
The blood tests should be performed to monitor the levels of magnesium in the patients.
Low white blood cells
Symptoms:fever,painin the neck, throat or mouth difficulty in urinating
Tightening of the smooth muscles of the lungs (bronchospasm)
Symptoms:suddenwheezingshortness of breath
Severe kidney problem (interstitialnephritis)
Inflammation of the brain
Severediarrhea
Your doctor has prescribed thismedicinebecause they judge that the benefit is greater than the risk posed byside-effects. Many people using this medicine do not have serious cases of side-effects. This page does not contain a complete list of all possible side-effects.
If you experience side-effects or notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
Produced by: Hikma pharmaceutical company
Imported by: abuubakar sadiiq pharmaceutical company