Glifix PLUS 15 mg 850 mg Pioglitazone Metformin for Type 2 Diabetes

Glifix PLUS 15 mg / 850 mg Film Coated Tablets combine two complementary antidiabetic agents, pioglitazone and metformin hydrochloride, to provide effective glycemic control in adults with type 2 diabetes mellitus.

Metformin primarily reduces hepatic glucose production and improves insulin sensitivity, while pioglitazone enhances peripheral insulin sensitivity by acting on adipose tissue and muscle cells. Together, they target different mechanisms of insulin resistance, leading to improved blood glucose regulation.

Glifix PLUS is typically prescribed when diet, exercise, and single agent therapy are insufficient to achieve adequate glycemic control. The fixed dose combination improves patient adherence by reducing pill burden and offering convenient twice daily or once daily dosing depending on medical advice.

Composition and Formulation

Each film coated tablet contains:
Active Ingredient :

• Pioglitazone 15 mg
• Metformin Hydrochloride 850 mg

Dosage Form: Film coated tablet
Route: Oral administration

Mechanism of Action

Pioglitazone works by:

• Activating peroxisome proliferator activated receptor gamma, PPAR gamma
• Increasing insulin sensitivity in muscle and adipose tissue
• Reducing insulin resistance

Metformin works by:

• Reducing hepatic glucose production
• Decreasing intestinal glucose absorption
• Improving peripheral glucose uptake
• Enhancing insulin sensitivity

The combination results in improved fasting and postprandial blood glucose levels.

Key Benefits

• Dual mechanism for improved glycemic control
• Reduces insulin resistance
• Helps lower fasting and post meal glucose levels
• Convenient fixed dose combination
• Supports long term diabetes management

Indications

Glifix PLUS 15 mg / 850 mg is indicated for:

• Type 2 diabetes mellitus in adults
• Patients inadequately controlled with metformin alone
• Patients requiring combination therapy for better glycemic control

It should be used alongside diet and exercise.

Dosage and Administration

Use as prescribed by a healthcare professional.
Usually taken with meals to reduce gastrointestinal side effects.
Swallow tablets whole with water.
Dose adjustment depends on patient response and tolerance.

Possible Side Effects

• Gastrointestinal discomfort
• Nausea or diarrhea
• Weight gain
• Edema
• Risk of hypoglycemia when combined with other antidiabetic agents

Consult a doctor if severe symptoms occur.

Precautions

Not recommended in patients with severe renal impairment.
Monitor liver function during therapy.
Use cautiously in patients with heart failure.
Temporarily discontinue before certain radiologic procedures with contrast media.

Storage

Store below 25°C.
Protect from moisture and light.
Keep out of reach of children.

Medical Disclaimer

The information provided on this website is for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment.

All medicines listed, including prescription drugs, should be used only under the supervision of a qualified healthcare professional. Always consult your doctor or pharmacist before starting, stopping, or changing any medication.